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KMID : 0357319950300060665
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Journal of the Korean Society for Microbiology
1995 Volume.30 No. 6 p.665 ~ p.670
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Immunoblot Analysis of Synovial Fluid from Arthritis Patients for IgG, IgM and IgA Antibodies Reacting with Rubella or Mumps Viruses
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Abstract
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Rubella and mumps viruses are known to be capable of causing acute arthritis. There are several evidences suggesting the association of viral infections and arthritis: about 70% of those who recovered from rubella complained arthralgia, rubella
and
mumps viruses could be cultivated in synovial tissue culture, and rubella virus has been isolated from the synovial fluid of arthritis patients.
This study was purposed to evaluate the relationship between acute arthritis and rubella or mumps viral infections. Synovial fluid aseptically aspirated from 24 Korean arthritis patients were analyzed by immunoblot assay for IgM and IgA
antibodies
reacting with rubella or mumps viral antigens. The results showed that IgG, igA antibodies against rubella viral antigens were detected in 75%(15/20), 85%(17/20) and 70%(14/20) of the analysed synovial fluid, respectively. Antibodies reacting
with
mumps
viral antigens were detected in 70.8%(17/24, IgG), 66.7%(16/24, IgM) and 54.2%(13/24, IgA), respectively. The high prevalence rate of antibodies reacting with rubella and/or mumps viruses in the synovial fluid from arthritis patients suggested
the
relationship between arthritis and the viral infections.
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KEYWORD
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